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Focusing on performance - by linking funding to the achievement of clear and measurable results - requires investment in measurement systems. Monitoring and evaluation is therefore critical to performance-based funding and must be integrated throughout the life cycle of every Global Fund grant.Three of the key challenges to performance-based funding at the Global Fund are ensuring that: (1) the indicators for grant performance measurement are appropriate and have baselines; (2) countries have adequate monitoring and evaluation systems to report on their achievements; and (3) data quality is assessed.