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The ACT-Accelerator Access to COVID-19 Tools Accelerator

A coordinated, global response to the pandemic is needed now more than ever. Only united can we fight COVID-19.

Our role in the
ACT-Accelerator

The Global Fund is a founding partner of the Access to COVID-19 Tools Accelerator (ACT-Accelerator). This global collaboration of leading public health agencies is working with governments, civil society and industry to accelerate the development and equitable distribution of tests, treatments and vaccines – and the strengthening of health systems – that the world needs to fight COVID-19.

The Global Fund is co-leading on two of the ACT-Accelerator’s four components – the Diagnostics Pillar and Health Systems Connector – and we are also supporting on procurement and distribution for the Therapeutics Pillar.

ACT-Accelerator progress

Targets

Since April 2020, the ACT-Accelerator partnership has supported the fastest, most coordinated, and successful global effort in history to develop tools to fight a disease. The ACT-Accelerator has driven real progress, delivering diagnostic tests, repurposed treatments, and vaccines.

By the end of 2021, the ACT-Accelerator aims to deliver 900 million diagnostic tests, 100 million courses of treatment and 2 billion doses of vaccine to low- and middle-income countries.

Yet inequity in access to COVID-19 tools remains unacceptably high, and new variants of concern continue to emerge around the globe. There is still much more to be done to fight this virus. Only united and through a comprehensive approach of all these interventions and tools can we defeat COVID-19.

The ACT-Accelerator
Funding Tracker
2021 Strategy and Budget
Quarterly Update: 1 April - 30 June 2021

Mobilizing more

The Global Fund is committed to working with our ACT-Accelerator partners to mobilize the funds needed for the global COVID-19 response, and to play our part in supporting low- and middle-income countries to deploy safe and effective diagnostics and treatments, protect health workers and strengthen health systems.

Diagnostics Pillar

Testing is the first line of defense against COVID-19. Without testing, we cannot track or contain the spread of the virus, address urgent clinical needs, test the efficacy of vaccination, and detect the emergence of new variants.

With the Foundation for Innovative New Diagnostics (FIND), the Global Fund co-leads the Diagnostics Pillar. The Pillar is working to ensure equitable access to testing tools, stimulate rapid and effective uptake of testing in countries, and drive the development and availability of high-quality, affordable and easy-to-use tests.

The Global Fund is focused on the procurement of antigen rapid diagnostic tests (Ag RDTs) and molecular polymerase chain reaction (PCR) tests, the strengthening of laboratory infrastructure and capacities, and significant requirements for training and technical assistance.

Find out more about the Diagnostics Pillar [ download in English ]

Find out more about the Global Fund's support for diagnostics

Therapeutics Pillar

WHO-recommended therapeutic treatments like corticosteroids and medical oxygen play a critical role in the COVID-19 response. Limited access to oxygen to treat COVID-19 is an emergency impacting more than half a million people in low- and middle-income countries every day. Ensuring treatments can be made available as soon as possible is particularly urgent to reduce the COVID-19 burden on health systems.

With WHO and Unitaid, the Global Fund co-leads the Therapeutics Pillar workstream on procurement and delivery of treatments for low- and middle-income countries. The Global Fund is also a key partner in the COVID-19 Oxygen Emergency Taskforce, which brings together key organizations working on oxygen access under the Therapeutics Pillar to measure oxygen demand, work with financing partners, and secure oxygen supplies and technical support for affected countries.

Find out more about the Global Fund's support for oxygen

Health Systems Connector

Co-led by the World Bank, WHO and the Global Fund, the Health Systems Connector equips health care workers with personal protective equipment (PPE) to safely deliver essential health services. The Health Systems Connector also supports countries in identifying and addressing key bottlenecks in order to effectively deploy diagnostic tests, therapeutic treatments and vaccines.

The Global Fund is engaged in all workstreams of the Health Systems Connector and focuses on the procurement of PPE, the strengthening of supply chains, and supporting community-led responses.

Find out more about the need to protect health workers

Find out more about the health systems connector

ACT-Accelerator progress

As of 17 August 2021

Diagnostics Pillar Progress

ACT-Accelerator

  • Over 98.1 million COVID-19 tests (38.2 million PCR tests and 59.9 million Ag RDTs tests) have been procured for low- and middle-income countries.
  • Over 23,000 health care workers are being trained in almost 200 countries to effectively implement the tests.
  • Over 90 RDTs have been independently assessed and benchmarked against quality criteria to inform government procurement of quality COVID-19 tests.
  • Fast-tracked access to affordable, high quality Ag RDTs for low- and middle-income countries has been secured. By working with industry and manufacturing partners on initiatives including scale up of local manufacturing, the Diagnostics Pillar has managed to cut the price of Ag RDTs in half since September 2020, from US$5 to US$2.5.
  • Regionalized manufacturing and technology transfers have been improved to increase global manufacturing capacity of quality and affordable RDTs in low- and middle-income countries.

The Global Fund, as part of ACT-Accelerator

As of 17 August 2021, the Global Fund has procured over 30.1 million diagnostic tests for 89 countries through the Global Fund’s Pooled Procurement Mechanism and/or on wambo.org.

  • 23.6 million Ag RDT tests procured across 42 countries
  • 4.7 million automated PCR diagnostic tests procured across 84 countries
  • 1.8 million manual PCR diagnostic tests procured

Therapeutics Pillar Progress

ACT-Accelerator

  • 3.2 million lifesaving dexamethasone treatments have been supplied (including 2.9 million by UNICEF)
  • Over 300 actionable trials across product categories have been tracked for monoclonal antibodies (mAbs), novel antivirals and repurposed therapeutics.
  • Research that identified dexamethasone as the first life-saving therapy for COVID-19 was supported and guidance provided on its use.
  • The Therapeutics Pillar has also analyzed over 1,700 clinical trials to identify promising COVID-19 treatments that could be scaled up, and funded multiple large-scale global clinical trials, including Recovery International and the ANTICOV trial. Recovery trials have started in Indonesia and Nepal, with Vietnam and Ghana following shortly. ANTICOV clinical trials have started in 13 African countries to test a new drug combination to treat mild-to-moderate COVID-19 cases.
  • Global guidance has been provided on the clinical use of corticosteroids (including dexamethasone) and its use integrated with medical oxygen into good clinical care to treat those severely affected.
  • The COVID-19 Oxygen Emergency Taskforce was formed to confront surges in oxygen demand and cut preventable deaths.
  • Memoranda of understanding (MoUs) have been signed with two multinational oxygen suppliers to pave the way for long-term agreements to widen access to liquid oxygen.

The Global Fund, as part of ACT-Accelerator

Following WHO recommendation, the Global Fund is supporting the use of corticosteroids for COVID-19. Global Fund implementers can include corticosteroids for COVID-19 in COVID-19 funding requests. Since August 2020, the Global Fund has made available the procurement of oxygen equipment products on wambo.org. The Global Fund has funded up to US$412 million for oxygen products as of 4 August 2021.

Health Systems Connector Progress

ACT-Accelerator

  • ACT-Accelerator partners have procured more than US$830 million in PPE for low- and middle-income countries.
  • Country readiness for the deployment of COVID-19 vaccines has been assessed in 128 LMICs.
  • Disruptions to 90% of health systems and services have been documented through national pulse surveys of more than 100 countries.
  • A “Transforming the Medical PPE Ecosystem” paper was produced as part of the 'Rethinking PPE’ initiative.
  • Global and regional guidance and training materials have been developed to support health financing and COVID-19 costing, strengthen community engagement in the COVID-19 response, bolster critical supply chain capabilities, and enhance engagement with the private sector and several other critical areas.

The Global Fund, as part of ACT-Accelerator

  • US$634 million of C19RM funds have been approved for the provision of personal protective equipment (PPEs):
    • C19RM 2021: US$358 million as of 4 August 2021
    • C19RM 2020: US$276 million in 2020
  • 59 countries have purchased PPEs on wambo.org.

ACT-Accelerator Funding

As of 13 August 2021 (Source: WHO)

Funding gap

  • US$16.6 billion

Total funds committed

Over US$18.1 billion

  • Vaccines: US$12.2 billion
  • Therapeutics: US$800 million
  • Diagnostics: US$1 billion
  • Health Systems: US$600 million
  • Pending allocation to/by pillars: US$3.1 billion

Learn more about our operational response to COVID-19

Response Mechanism

Published 14 April 2021

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