Seventh Replenishment Investment Case Fight For What Counts

Over the past 20 years, our unique partnership has invested more than US$53 billion, saving 44 million lives and reducing the combined death rate from HIV, tuberculosis (TB) and malaria by more than half in the countries in which the Global Fund invests.

For the Seventh Replenishment, the Global Fund needs at least US$18 billion. This is the minimum required to get the world back on track toward ending HIV, TB and malaria, to build resilient and sustainable systems for health and strengthen pandemic preparedness, making the world more equitable and safer from future threats.

The stakes could not be higher. The last two years have been a vivid demonstration of how old and new pandemics interact. COVID-19 has been a catastrophe for those most affected by HIV, TB and malaria. If we do not meet our new investment target, many more people will die from these pandemics and be at risk from future health threats.

These funds are needed to change the trajectories of mortality and incidence toward achieving the SDG 3 target of ending AIDS, TB and malaria as epidemics by 2030, build stronger and more resilient health systems and strengthen capacities to prevent and prepare for future pandemics. By taking an integrated approach to the pursuit of these complementary objectives, we can maximize the impact of every dollar.

The Global Fund’s target for the Seventh Replenishment is to raise at least US$18 billion. This scale of investment is essential: If we do not reach this goal, we will fail.

Our investment case lays out how we plan to fight for what counts and protect everyone, everywhere from the deadliest infectious diseases and build a healthier, more equitable world.

Seventh Replenishment Investment Case
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Overall Resource Needs and Projected Available Resources for HIV, TB and Malaria in Countries Where the Global Fund Invests

Securing at least US$18 billion for the Global Fund would:

Help get the world back on track to end AIDS, TB and malaria:

Save 20 million lives
Reduce the death toll across the three diseases
Avert more than 450 million infections or cases

Accelerate progress toward SDG 3 and universal health coverage and strengthen pandemic preparedness:

Catalyze scale-up of domestic investments of up to US$59 billion
Reinforce systems for health and pandemic preparedness
Yield a return on investment of 1:31
Reduce inequities in health services

Getting back on track against HIV, TB and malaria is essential. Even before COVID-19, we were off track compared to the trajectories for reductions in infections and deaths prescribed by the Global Plans for HIV, TB and malaria.

Taking a smarter, less siloed and more integrated approach to fighting HIV, TB and malaria, combating COVID-19 and building pandemic preparedness will enable us to address all three challenges on a highly efficient, marginal cost basis. By supplementing disease-specific investments with increased investments in surge capacity and multipathogen capabilities, we can simultaneously deliver immediate benefits to countries and communities in terms of lives saved and infections averted, and strengthen the ability of health systems to prevent, detect and respond to future threats.

How US$18 Billion Supports HIV, TB and Malaria Programs and Strengthens Health Systems for Resilience, Sustainability and Pandemic Preparedness

In 2002, the Global Fund was founded to fight HIV, TB and malaria – three global pandemics that were killing millions of people every year. Over the last 20 years, we have built a strong and vibrant alliance that has brought together thousands of diverse organizations in a unique partnership to confront the world’s deadliest infectious diseases across more than 120 countries.

In the last two years, that partnership has also played a crucial role in the global fight against COVID-19. Those efforts have achieved tremendous impact, saving more than 44 million lives. Our partnership will continue to play a critical role as the world seeks to accelerate progress toward ending AIDS, TB and malaria as public health threats by 2030, defeat COVID-19 and build better defenses against future pandemics.

Read the results report

Fight for What Counts: People and Impact

We have faced impossible odds before, and we can do it again. When the Global Fund was created 20 years ago, HIV, TB and malaria seemed unbeatable. But we have proven that with science, adequate resources and effective global collaboration, we can force even the deadliest diseases into retreat.

Nhin Kpă From La Rsươm, Viet Nam

Mozambique: Transforming the National Laboratory System in Response to COVID-19

Bryanna Nicole Camey From Guatemala City, Guatemala

Djibouti: Women-run Mobile Brigades Fight HIV and COVID-19 Together

Bangladesh: Rapid Recovery of Tuberculosis Case Notifications

Maia’s Story: Mobile App Transforms Drug-resistant TB Treatment

Kamate Muhindo From Goma, Democratic Republic of the Congo

Dr. Jayanthi Shastri From Mumbai, India

Ukraine: Breaking Down Human Rights Barriers to Accelerate the Fight Against HIV

Niger: Fighting Malaria with Evidence and Innovation

Zambia: Solar Power Fuels Better Health

Carolyne’s Fight: Ending HIV and Gender-Based Violence

Find out more

Every US$100 million invested through the Global Fund to support HIV, TB and malaria programs will:

Save 113,000 lives through programs supported by the Global Fund, and;

Avert 2.5 million new infections or cases across the three diseases, and;

Create US$2.9 billion in economic returns through health gains, and;

Provide antiretroviral therapy for 156,000 people, and;

Provide medicine for 15,000 mothers to prevent transmitting HIV to their babies, and;

Provide HIV counselling and testing for 4.3 million people, and;

Reach 259,000 members of key population with prevention programs, and;

Provide TB treatment and care for 98,000 people, and;

Screen 1.8 million people for TB, and;

Provide 3,700 people with treatment for multidrug-resistant TB, and;

Provide antiretroviral therapy for 4,900 HIV-positive TB patients, and;

Distribute 7.6 million mosquito nets to protect children and families from malaria, and;

Provide 40,000 seasonal malaria chemoprevention to protect children and families from malaria, and;

Provide malaria treatment and care for 1.6 million people.

Estimates are derived from the modelling conducted to estimate impact of the Global Fund 2023-2025 Investment Case. To estimate the results of a given financial contribution to the Global Fund, first the current upfront disease split in the Global Fund allocation model is assumed, then results are derived by assuming a linear relationship between funding and results. An overhead count of 5% is deducted from the amount.

The Global Fund supports a range of interventions recommended by technical partners, which go beyond those presented in the results of this calculator.

The results reflect contributions of Global Fund investments to national programs and their results. The Global Fund strongly advises that, in using the numbers, it is important to clarify that these results are achieved together with partners.

Seventh Replenishment Investment Case Fight For What Counts

Fight for What Counts: People and Impact

Every US$100 million invested through the Global Fund to support HIV, TB and malaria programs will:

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