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The vision of the Global Fund is to achieve a world free of the burden of HIV, TB and malaria. The strategy is to invest for impact.

The impact of investments in health can be measured in many ways, including how many lives are saved, and the rate of decline in HIV, TB and malaria, and other methods. In a broad sense, the real impact of investments in health is the vitality and economic strength of communities and countries where the burden of disease is retreating. 

AIDS, TB & Malaria: End It. For Good.

The Global Fund marks the tremendous progress made collectively by partners in the fight against AIDS, TB and malaria, and calls for a renewed commitment to accelerating the end of these epidemics. 20 million lives have already been saved by Global Fund-supported programs, and defeating these diseases could be among our generation’s greatest achievements. We can’t stop now.

Lives saved

The Global Fund partnership supports programs that have saved more than 20 million lives at the end of 2015. Current projections show that more than 2 million lives are being saved each year. If current trends hold, by the end of 2016 the Global Fund partnership will have supported countries in saving more than 22 million lives.

In 2000, AIDS, TB and malaria appeared to be unstoppable. Hard work by many partners has succeeded in reversing the situation, by creating significant advances in prevention and increased access to treatment and care for people affected by the diseases. Investments by the Global Fund partnership have grown aggressively, supporting a dramatic expansion of antiretroviral therapy, treatment of TB patients, and distribution of insecticide-treated nets, as well as building resilient and sustainable systems for health.

The Global Fund Strategy 2012-2016 set a target of saving 10 million lives in the five-year period ending 31 December 2016. Current projections are on track to achieve that milestone. The Global Fund has met and is on track to exceed the Global Fund Strategy 2012-2016 target of averting 140-180 million infections by the end of 2016.

Decline in HIV burden

The number of AIDS-related deaths is declining. In countries where the Global Fund invests, the death rate declined more than 45 percent, from 1.9 million in 2004 to 1.1 million in 2015.

The rapid increase in access to antiretroviral (ARV) therapy in countries supported by the Global Fund, from 3.3 percent coverage in 2005 to 21 percent in 2010 and 45 percent coverage in 2015, has been a tremendous contributing factor.

The number of HIV infections is falling. Between 2000 and 2015, the number of HIV infections declined by 37 percent in countries supported by the Global Fund. Partners express optimism that the rate of averting infections can accelerate more sharply if funding continues to grow. Another important factor is the expansion of national coverage of prevention of mother-to-child transmission, reaching 49 percent coverage in 2010 and 76 percent in 2015.

Decline in TB burden

The number of deaths from TB declined 31 percent between 2000 and 2015 in countries where the Global Fund invests. (Deaths from co-infection of HIV and TB are not included in that number.)

The number of deaths from TB in 2015 would have been more than three times higher in the absence of interventions. The global burden of TB is disproportionately borne by 30 high-burden countries, and efforts on treatment and prevention are being concentrated there.

The decline in deaths was supported by an increase in the number of TB cases detected and treated over the past decade.

Decline in malaria burden

The number of deaths globally caused by malaria declined 48 percent between 2000 and 2015. The number of lives saved by malaria treatment and prevention has grown steadily each year. Children under the age of five are the most vulnerable to malaria, because their immune systems are still developing effective resistance to the disease. Pregnant women are also vulnerable, because their immune systems are weakened during pregnancy. Protecting young children and pregnant women is paramount to any disease strategy.

The innovation of a long-lasting insecticidal mosquito net, at a relatively low cost, has greatly expanded protection for children and families. With more than 713 million mosquito nets distributed as of mid-2016, people at risk for malaria who gained access to mosquito nets grew from 7 percent in 2005 to 35 percent in 2010 and 62 percent in 2015 in countries where the Global Fund invests.

Mosquito nets are just one tool, however, and a comprehensive approach to reducing deaths from malaria includes other preventive measures such as indoor residual spraying. More important, access to artemisinin-based combination therapies (ACTs) and to rapid diagnostic tests has improved dramatically. Cases of malaria treated rose to a cumulative 626 million by mid-2016.


Programs supported by the Global Fund have achieved breathtaking progress in the fight against HIV, TB and malaria. Together, the partnership has saved 20 million lives. Behind that number are the individuals whose courage and commitment are driving this progress. Join them! Watch and share this video – be part of the generation to end AIDS, TB and malaria as epidemics.

Published 15 January 2017