Step Up the Fight The Global Fund Sixth Replenishment

In 2019 the Global Fund called on the world to step up the fight against HIV, tuberculosis and malaria. We released our Investment Case and launched the Sixth Replenishment to raise at least US$14 billion to help save 16 million lives, avert 234 million infections and help the world get back on track to end these diseases.

The world faces a choice

A successful Sixth Replenishment means…

Our Investment Case outlined what the Global Fund partnership can achieve with the target US$14 billion for the three-year cycle beginning in 2020.

Help get the world back on track to end HIV, tuberculosis and malaria:

  • Save 16 million lives between 2021 and 2023, reducing the mortality rate by 52 percent across the three diseases by 2023, relative to 2017 levels.
  • Reduce the death toll across the three diseases to 1.3 million in 2023, down from 2.5 million in 2017, and from 4.1 million in 2005.
  • Avert 234 million infections or cases reducing the incidence rate by 42 percent across the three diseases by 2023, relative to 2017 levels.

Accelerate progress toward SDG 3 and universal health coverage:

  • Strengthen health care systems through directly investing approximately US$4 billion to build capacities such as diagnostic tools, surveillance systems, supply chain management and training for health care workers, and accelerating the shift toward patient-centered, differentiated models of care.
  • Reinforce health security by helping build more resilient health systems, with stronger surveillance, diagnostic and emergency response capabilities, and by directly tackling key threats to global health security, such as multidrug-resistant TB.
  • Yield a return on investment of 1:19 with every dollar invested resulting in US$19 in health gains and economic returns, further contributing to the achievement of the overall SDG agenda.
  • Spur domestic investment of US$46 billion toward ending the three diseases and strengthening health systems through cofinancing requirements, and technical assistance on health financing.
  • Tackle inequities in health including gender- and human rights-related barriers to access, by working with partners, including civil society and affected communities, to build more inclusive health systems that leave no one behind.

The Global Fund will contribute to achieving these results alongside sustained levels of other external funding, scaled-up domestic financing, and more innovation, collaboration and rigorous execution.

The Investment Case, Presented by Peter Sands

Our promise to 7-year-olds everywhere

While today’s adults are leaving the next generation with a long to-do list, we made a promise to 7-year-olds everywhere to do everything we can to end AIDS, TB and malaria by 2030, so they don’t have to. More than 100,000 people signed our open letter to 7-year-olds around the world – the group that turns 18 in 2030.

Faces of the fight

The fight against HIV, TB and malaria has many faces. They span ages and geographies and gender. Their diversity shows us that these diseases don’t affect one “type” of person. We can all see ourselves in these champions – in their challenges, their hopes and their strength.

Meet some of the faces

Learn more about the success of our Sixth Replenishment.