Step Up the Fight

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The Global Fund Seeks to Raise at least US$14 Billion to Step Up the Fight Against AIDS, TB and Malaria

The Sixth Replenishment

The Global Fund is calling on the world to step up the fight against HIV, TB and malaria. We are just months away from a crucial moment in the fight against the diseases. In October 2019, President Macron will host the Global Fund’s Sixth Replenishment Conference in Lyon. This Replenishment seeks to raise at least US$14 billion to help save 16 million lives, avert 234 million infections and help the world get back on track to end these diseases. Of the at least US$14 billion, the Global Fund is calling on the private sector to mobilize at least US$1 billion to step up the fight.

Stepping up the fight should not be seen as a choice, but as the fulfilment of a promise. This moment presents us with an opportunity to take a massive step toward achieving Sustainable Development Goal 3: health and well-being for all. We have no time to waste and we are calling on the world to step up the fight. Now.


Ending the epidemics of HIV, tuberculosis and malaria by 2030 is within reach, but not yet fully in our grasp. With only 11 years left, we have no time to waste. We must step up the fight now.

The Investment Case, Presented by Peter Sands

Meet Moustarida

Moustarida, age 3, is one of more than 4 million children under 5 in Niger alone to receive seasonal malaria chemoprevention (SMC). During the rainy season, when malaria strikes the most, community health workers dispense SMC to protect young children from the disease.

As the leading international funder of the malaria response, the Global Fund is investing in new tools, data generation, partnerships and innovations – including piloting new mosquito nets to combat insecticide resistance in Africa.

Photo: The Global Fund / Fonds mondial / David O’Dwyer
Photo: The Global Fund / Fonds mondial / Vincent Becker

Meet Anastasia

Anastasia is 17 and she’s in the fight of her life. She has multidrug-resistant tuberculosis. TB is today’s most deadly infectious disease, and deaths from drug resistant TB account for about one-third of all antimicrobial resistance deaths worldwide.

We are not on track to meet the goal of ending TB by 2030. But if we step up now, we can achieve a decisive change in trajectory. In the fight against TB, now is the moment.

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Meet Aftab Ansari

Aftab Ansari left his village in northern India to work as a diamond cutter in Mumbai. But his dreams for a better life for his family suffered a blow when he got drug-resistant tuberculosis. Aftab, 32, is today back at work and paying his debts after completing the treatment that cured his TB.

Infectious diseases like TB put an enormous financial burden on households worldwide, particularly in lower-income countries, draining billions in medical costs and lost productivity.

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Photos: The Global Fund / Fonds mondial / Vincent Becker
Photo: The Global Fund / Fonds mondial / Brett Gieseke

Meet Goodness & Nqabile

Goodness Mbatha and Nqabile Mbatha are more than mother and daughter, and their bond is clear to all who meet them. When Goodness got pregnant with Nqabile at 23, she knew she was living with HIV. She enrolled on treatment to prevent passing HIV to Nqabile and succeeded.

To end high HIV infections among young women and girls in the country, the Global Fund partnership is investing in programs that challenge harmful gender norms, discrimination, and violence against women.

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Meet Chang Chai

Chang Chai is a construction worker from Myanmar living on the outskirts of Chiang Mai, Thailand. He’s the go-to guy for health information in the settlement of about 10 migrant families.

Solutions require action and engagement at all levels – from volunteer community leaders like Chang Chai, to robust civil society organizations like MAP and national policies that support achieving universal health coverage.

Photo: Jonas Gratzer

US$14 billion for the Global Fund would...

Help get the world back on track to end HIV, tuberculosis and malaria:

  • Save 16 million lives between 2021 and 2023, reducing the mortality rate by 52 percent across the three diseases by 2023, relative to 2017 levels.
  • Reduce the death toll across the three diseases to 1.3 million in 2023, down from 2.5 million in 2017, and from 4.1 million in 2005.
  • Avert 234 million infections or cases reducing the incidence rate by 42 percent across the three diseases by 2023, relative to 2017 levels.

Accelerate progress toward SDG 3 and universal health coverage:

  • Strengthen health care systems through directly investing approximately US$4 billion to build capacities such as diagnostic tools, surveillance systems, supply chain management and training for health care workers, and accelerating the shift toward patient-centered, differentiated models of care.
  • Reinforce health security by helping build more resilient health systems, with stronger surveillance, diagnostic and emergency response capabilities, and by directly tackling key threats to global health security, such as multidrug-resistant TB.
  • Yield a return on investment of 1:19 with every dollar invested resulting in US$19 in health gains and economic returns, further contributing to the achievement of the overall SDG agenda.
  • Spur domestic investment of US$46 billion toward ending the three diseases and strengthening health systems through cofinancing requirements, and technical assistance on health financing.
  • Tackle inequities in health including gender- and human rights-related barriers to access, by working with partners, including civil society and affected communities, to build more inclusive health systems that leave no one behind.

With a Sixth Replenishment of at least US$14 billion for the three-year cycle beginning in 2020, the Global Fund would contribute to achieving these results alongside sustained levels of other external funding scaled-up domestic financing, and more innovation, collaboration and rigorous execution.

To achieve the SDG 3 targets of ending the epidemics and creating resilient health systems to deliver health and well-being for all, we must step up the fight now.

Published 05 June 2019