Step Up the Fight

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The Global Fund Seeks to Raise at least US$14 Billion to Step Up the Fight Against AIDS, Tuberculosis and Malaria

The Sixth Replenishment

The Global Fund is calling on the world to step up the fight against HIV, TB and malaria. We are just months away from a crucial moment in the fight against the diseases. In October 2019, President Macron will host the Global Fund’s Sixth Replenishment Conference in Lyon. This Replenishment seeks to raise at least US$14 billion to help save 16 million lives, avert 234 million infections and help the world get back on track to end these diseases. Of the at least US$14 billion, the Global Fund is calling on the private sector to mobilize at least US$1 billion to step up the fight.

Stepping up the fight should not be seen as a choice, but as the fulfilment of a promise. This moment presents us with an opportunity to take a massive step toward achieving Sustainable Development Goal 3: health and well-being for all. We have no time to waste and we are calling on the world to step up the fight. Now.


Ending the epidemics of HIV, tuberculosis and malaria by 2030 is within reach, but not yet fully in our grasp. With only 11 years left, we have no time to waste. We must step up the fight now.

The Investment Case, Presented by Peter Sands

Our promise to 7-year-olds everywhere

While today’s adults are leaving the next generation with a long to-do list, we’re making a promise to 7-year-olds everywhere to do everything we can to end AIDS, TB and malaria by 2030, so they don’t have to. Sign our open letter to 7-year-olds around the world – the group that turns 18 in 2030.

Sign the open letter

Faces of the fight

The fight against HIV, TB and malaria has many faces. They span ages and geographies and gender. Their diversity shows us that these diseases don’t affect one “type” of person. We can all see ourselves in these champions – in their challenges, their hopes and their strength.

Learn more

The Global Fund / Joubert Loots

US$14 billion for the Global Fund would...

Help get the world back on track to end HIV, tuberculosis and malaria:

  • Save 16 million lives between 2021 and 2023, reducing the mortality rate by 52 percent across the three diseases by 2023, relative to 2017 levels.
  • Reduce the death toll across the three diseases to 1.3 million in 2023, down from 2.5 million in 2017, and from 4.1 million in 2005.
  • Avert 234 million infections or cases reducing the incidence rate by 42 percent across the three diseases by 2023, relative to 2017 levels.

Accelerate progress toward SDG 3 and universal health coverage:

  • Strengthen health care systems through directly investing approximately US$4 billion to build capacities such as diagnostic tools, surveillance systems, supply chain management and training for health care workers, and accelerating the shift toward patient-centered, differentiated models of care.
  • Reinforce health security by helping build more resilient health systems, with stronger surveillance, diagnostic and emergency response capabilities, and by directly tackling key threats to global health security, such as multidrug-resistant TB.
  • Yield a return on investment of 1:19 with every dollar invested resulting in US$19 in health gains and economic returns, further contributing to the achievement of the overall SDG agenda.
  • Spur domestic investment of US$46 billion toward ending the three diseases and strengthening health systems through cofinancing requirements, and technical assistance on health financing.
  • Tackle inequities in health including gender- and human rights-related barriers to access, by working with partners, including civil society and affected communities, to build more inclusive health systems that leave no one behind.

With a Sixth Replenishment of at least US$14 billion for the three-year cycle beginning in 2020, the Global Fund would contribute to achieving these results alongside sustained levels of other external funding scaled-up domestic financing, and more innovation, collaboration and rigorous execution.


To achieve the SDG 3 targets of ending the epidemics and creating resilient health systems to deliver health and well-being for all, we must step up the fight now.

Published 16 August 2019