# Investment Case Technical Annexes

All Annexes
[download](/media/15416/core_2025-investment-case-all-annexes_annex_en.pdf "core_2025-investment-case-all-annexes_annex_en.pdf")

The technical annexes describe in detail the modeling analyses, methodology and data sources used for the estimated projections and figures in the Investment Case.

- Annex 1 - Methodology for estimating the resource needs for HIV, TB and malaria
[download](/media/15382/core_2025-investment-case-methodology-resource-estimate_annex_en.pdf "core_2025-investment-case-methodology-resource-estimate_annex_en.pdf")
- Annex 2 - Methodology for the projection of available resources for HIV, TB and malaria
[download](/media/15383/core_2025-investment-case-methodology-resource-projection_annex_en.pdf "core_2025-investment-case-methodology-resource-projection_annex_en.pdf")
- Annex 3 - Methodology for impact modeling
[download](/media/15384/core_2025-investment-case-methodology-impact-modeling_annex_en.pdf "core_2025-investment-case-methodology-impact-modeling_annex_en.pdf")
- Annex 4 - Methodology for return on investment (ROI) calculations
[download](/media/15385/core_2025-investment-case-methodology-roi_annex_en.pdf "core_2025-investment-case-methodology-roi_annex_en.pdf")
- Annex 5 - Methodology for calculations on health inequality across countries
[download](/media/15386/core_2025-investment-case-methodology-health-inequality_annex_en.pdf "core_2025-investment-case-methodology-health-inequality_annex_en.pdf")
- Annex 6 - Methodology to estimate impact of HIV, TB and malaria investments on utilization of primary health care
[download](/media/15387/core_2025-investment-case-methodology-primary-health-care_annex_en.pdf "core_2025-investment-case-methodology-primary-health-care_annex_en.pdf")
- Annex 7 - Methodology to estimate the benefits of investing in health systems to reduce the burden of HIV, TB and malaria as well as other conditions
[download](/media/15388/core_2025-investment-case-methodology-human-resources-health_annex_en.pdf "core_2025-investment-case-methodology-human-resources-health_annex_en.pdf")
- Annex 8 - Global plan milestones and targets
[download](/media/15389/core_2025-investment-case-global-plan-milestones-targets_annex_en.pdf "core_2025-investment-case-global-plan-milestones-targets_annex_en.pdf")
- Annex 9 - Upcoming market-shaping efforts for the introduction of new health products
[download](/media/15379/core_2025-investment-case-global-plan-market-shaping-health-products_annex_en.pdf "core_2025-investment-case-global-plan-market-shaping-health-products_annex_en.pdf")