News Releases

Global Fund Partners Demonstrate Unity and Resolve to Sustain Progress and Strengthen Global Health Security

US$11.34 billion raised amid global challenges marks renewed solidarity and sets the stage for a transformed, more resilient global health system.

21 November 2025

JOHANNESBURG/GENEVA – The Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) held its Eighth Replenishment Summit today in Johannesburg, South Africa, co-hosted by the governments of the Republic of South Africa and the United Kingdom on the margins of the G20 Leaders’ Summit. Despite one of the most turbulent geopolitical and economic years in recent memory, partners around the world pledged US$11.34 billion to sustain the fight against AIDS, tuberculosis (TB) and malaria, save millions more lives, and strengthen systems for health. 

The Summit also marked a renewed commitment to work differently – embracing a more agile, country-driven form of partnership that can adapt to a rapidly changing global health landscape, mobilize new donors, and accelerate domestic resource mobilization for health.

The outcome represents a powerful demonstration of unity and resolve in a period defined by fiscal tightening, conflict and global uncertainty. While total pledges fall short of the ambitious target set in the Investment Case, and several donors have yet to confirm their pledges, this Replenishment nevertheless reaffirms that global solidarity remains strong – and that the world can come together to confront these three epidemics and protect future generations.

Renewed leadership and solidarity

At the Summit, H.E. President Cyril Ramaphosa of South Africa underlined Africa’s growing leadership in global health.

“Hosting this Replenishment on African soil for the first time symbolizes how far we have come – and how far we can go,” he said. “Africa is not only leading in implementation; we are also driving innovation and taking greater responsibility for our own health systems. This partnership embodies solidarity, equity and transformation.”

Five Heads of State and Government, and representatives from 17 countries, joined the gathering alongside multilateral partners, philanthropies, businesses, civil society and community networks. Their unity sent a powerful message: The fight against AIDS, TB and malaria is not over – and global resolve to advance progress remains strong. 

Rt. Hon. Sir Keir Starmer, Prime Minister of the United Kingdom, stressed the value of investing in the Global Fund.

“In today’s volatile world, we must prioritise spending that makes a genuine difference and supports both growth at home and globally,” he said. 

“That is why we will continue to support the Global Fund, whose work is at the cutting edge of fighting the world’s deadliest diseases. It is an investment in economic growth and stability, and a prime example of our modern approach to development.”

Strong commitments across sectors

Even amid economic headwinds and competing global priorities, partners reaffirmed their confidence in the Global Fund’s impact.

The United Kingdom, as co-host, pledged GBP 850 million for lifesaving prevention, testing and treatment services, emphasizing that this is a strategic investment in global and national health security and in economic growth and stability. South Africa committed US$36.6 million, a joint public–private pledge that includes an increased government contribution, which more than doubled from the last Replenishment, and financing from the South African private sector amounting to US$10 million, exemplifying Africa’s dual role as both implementer and investor.

The United States, the Global Fund’s largest donor, committed US$4.6 billion in recognition of the Global Fund’s role as an essential partner that scales innovations with a world-class pooled procurement mechanism and supports critical frontline health care workers. 

Many long-term partners reaffirmed their commitment to the Global Fund and noted the many strengths of the Global Fund model. Germany confirmed their pledge of €1 billion, while France noted that their support to the Global Fund remains unchanged, but they would only be in a position to confirm their pledge next month. Founding donor Canada pledged CAD 1.02 billion. Spain increased their pledge to €145 million, with Italy pledging €150 million and the Netherlands contributing €146 million. Australia and Norway maintained their respective commitments.

Other donors, such as India and Ireland, increased their contributions, reflecting continued leadership from G20 countries. Korea maintained its strong commitment to the Global Fund and now qualifies to join a voting constituency of the Global Fund Board, the first time this has happened since 2006. Commitments from the G20 member states reached US$8.96 billion, reflecting the consensus that the Global Fund is a worthwhile investment in advancing global health. Through these commitments, donors highlighted the Global Fund’s critical role in advancing global health security by strengthening surveillance, expanding regional manufacturing capacity and supporting countries to prevent, detect and respond to future health threats.

A number of African countries, all of whom are also implementers of Global Fund grants, made solidarity commitments totaling US$51.59 million. They noted their pride in announcing these commitments at the first Replenishment to be held on the African continent. In making their pledges, African leaders highlighted the significant progress they are making in financing their own health systems to meet the needs of their citizens.

Private sector driving impact and innovation

The private sector played a defining role: The Gates Foundation, the Global Fund’s largest private donor, pledged US$912 million. The Children’s Investment Fund Foundation (CIFF) pledged a further US$135 million, taking their total additional commitment to US$200 million since the Seventh Replenishment, a significant increase from their previous pledges. (RED) continued its nearly two-decade partnership with a US$75 million commitment, and other private donors committed a total of US$201.85 million to bring overall Eighth Replenishment support to US$1.34 billion so far, with more pledges to come. Together these investments will accelerate access to new tools, underpin health systems strengthening and global health security work, and support integration to increase efficiency and improve outcomes for women and children.

A model that works – and evolves

Lady Roslyn Morauta, Chair of the Global Fund Board, said the outcome reflects both resilience and renewal.

“In a difficult year, this result shows the world’s confidence in our collective model and its enduring power to deliver results,” she said. “But it also shows our determination to adapt – to work smarter, be more efficient and ensure that every dollar delivers maximum impact.”

The Global Fund model – country-owned, performance-based and community-driven – remains a benchmark for inclusive global health partnerships. Yet partners agree it must continue to evolve. In line with the principles reaffirmed through the Accra Reset, the Global Fund will continue to support countries on the path to nationally led, nationally financed health systems, simplify grant processes, and expand access to pooled procurement so countries can purchase lifesaving commodities at the lowest cost. This evolution also depends on deeper collaboration across the global health ecosystem – including enhanced collaboration with the World Health Organization, the African Union, Gavi, the Vaccine Alliance and other partners. 

In parallel, the partnership will step up efforts to support the mobilizing of greater domestic resources for health, ensuring countries sustain and grow their own investments to strengthen systems, scale innovations and drive progress toward universal health coverage.

“Today’s commitments signal a powerful shift toward partnerships that put countries in the lead, drive innovation, and mobilize sustainable financing for health,” said H.E. President Bola Ahmed Tinubu of Nigeria. 

“For Nigeria, this aligns with our deepening investment in our own health system – from expanding primary health care to strengthening surveillance and deploying new tools that bring lifesaving services closer to our people. This renewed spirit of solidarity reinforces our determination to build a more resilient, equitable health system and advance universal health coverage, ensuring that every community, no matter how remote, can access quality care.”

Looking ahead, the Global Fund is committed to accelerating this collaborative shift – moving from parallel efforts to shared delivery pathways, coordinated investments, and country-led platforms that reduce duplication and unlock faster, more sustainable impact.

Building on these commitments, Peter Sands, Executive Director of the Global Fund, framed the outcome as both an achievement and an urgent call for transformation.

“This is a remarkable moment. In a year when many predicted the end of global solidarity, our partners have proven otherwise,” he said. “Thanks to the steadfast commitment of our donors and partners, this Replenishment delivered a remarkable outcome from a remarkable partnership. It shows what the world can achieve when we stand together, even in the toughest of times.”

“These pledges will save millions more lives, but they also mark a turning point. Our model remains strong – but the world around us is changing. We must keep evolving: becoming smarter, faster and more efficient, and ensuring the entire global health system works better for the people it serves.”

Sands highlighted how innovation at scale – from portable digital X-rays to AI for TB screening to long-acting HIV prevention to dual active ingredient insecticide-treated mosquito nets – is reshaping the fight. “Time equals lives; scale equals impact,” he said, committing to a 20% reduction in operating costs and a faster, more data-driven approach to delivery.

Building resilience and transforming the way we work

The funds raised through the Eighth Replenishment will not only sustain lifesaving programs, but also deepen investment in resilient and sustainable systems for health. The Global Fund is the largest multilateral grant funder of health systems strengthening, with over US$2.7 billion invested in oxygen provision, laboratories, data systems and health workforce training in 2024 alone. These investments benefit all health priorities and reinforce global pandemic preparedness.

Sands noted that such efficiency and collaboration will be critical in a tighter fiscal era: “Money will always be tight, so we must be smarter – strengthening countries’ self-reliance by boosting domestic resource mobilization, improving public financial management, supporting the growth of regional manufacturing and leveraging pooled procurement. That’s how we build durable systems that can deliver impact long after this Replenishment cycle.”

Communities remain at the heart

For Cecilia Lodonu-Senoo, speaking on behalf of the Communities, Developing Country NGOs and Developed Country NGOs Delegations to the Global Fund Board, the pledges made in Johannesburg carry deep meaning.

“For people living with HIV, and for families affected by TB and malaria, these commitments mean access, dignity and hope,” she said. “Communities have always been at the center of this fight – and we will remain at the heart of what comes next.”

Looking ahead: A partnership for a new era

The Eighth Replenishment marks the beginning of a new phase for the Global Fund – one defined by transformation, innovation and shared responsibility. As remaining pledges are finalized, the partnership will keep its focus on delivering maximum impact, ensuring resources are translated swiftly and effectively into country programs. With allocations to be agreed at the February Board meeting, partners are committed to sustaining momentum and keeping pressure on the system to align ambition with need.

The new Grant Cycle Eight strategy over the next three years underscores how the partnership will work smarter – leveraging cutting-edge tools, strengthening efficiencies and doing more with less – while supporting governments, communities and partners to build a global health ecosystem that is simpler, more coherent and more responsive to country priorities.

These investments will also yield substantial economic returns, strengthening workforce productivity, stabilizing economies and contributing to long-term, inclusive growth.

“Together we can end AIDS, TB and malaria,” Sands concluded. “We can build the first generation free from the threat of these diseases – and a global health ecosystem that is faster, fairer and stronger. This Replenishment demonstrates the world’s determination to keep driving forward – proving that even in difficult times, innovation and partnership can prevail.”