Global Fund Private Sector Partners to Drive Innovation, Equity, Access and Impact in Global Health
US$1.34 billion raised so far from private sector partners for the Global Fund’s Eighth Replenishment to drive innovation, access and resilient health systems for the most vulnerable.
21 November 2025
Pledges at Global Fund Eighth Replenishment Conference
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Pledges at Global Fund Eighth Replenishment Conference - Private Sector and Non-Government Donors
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JOHANNESBURG/GENEVA – Against the backdrop of economic and geopolitical instability, the private sector has responded to a call to action from the Global Fund to Fight AIDS, Tuberculosis and Malaria (the Global Fund) with urgency and conviction. Private sector and philanthropic partners have mobilized a remarkable US$1.34 billion for the Global Fund’s Eighth Replenishment, co-hosted by the governments of the Republic of South Africa and the United Kingdom on the margins of the G20 Leaders’ Summit.
This results in a total of US$1.49 billion that has been mobilized since the Seventh Replenish-ment conference in 2022 – marking the largest surge of private sector support in the Global Fund’s history.
This unprecedented scale and pace of commitment signal the private sector’s deep resolve to accelerate innovation, advance equity and strengthen resilient health systems – while driving lifesaving progress against AIDS, tuberculosis (TB) and malaria worldwide.
Private funding can be deployed rapidly, enabling the Global Fund to accelerate countries’ ac-cess to tools like lenacapavir and to fast-track the rollout of next-generation TB diagnostics – ensuring that the most effective tools reach communities faster and more equitably.
“What we are witnessing here is the power of bold, agile leadership,” said Peter Sands, Executive Director of the Global Fund. “The private sector has stepped forward at a critical moment, acting swiftly and at scale to save lives and spur the engagement of other stakeholders.” He added: “Now we must build on this momentum. We invite others to join us in demonstrating how private sector dollars and capabilities can have such extraordinary catalytic impact.”
From global corporations to philanthropic funds, 21 companies, foundations and philanthropists have joined the effort. Private sector partners are shaping market pathways, strengthening in-tegrated health systems, and advancing scalable solutions for the vulnerable communities most at risk.
The Gates Foundation, the Global Fund’s largest private donor, pledged US$912 million in September, bringing its total contributions since 2002 to nearly US$5 billion. (RED) renewed its long-standing partnership with a US$75 million commitment. The Children’s Investment Fund Foundation (CIFF) pledged US$50 million to accelerate the rollout of TB diagnostics, building on its earlier US$150 million investment to break the cycle of HIV transmission, some of which is already being put into action in the current grant cycle.
A broad coalition of private sector and philanthropic partners stepped forward with renewed commitments, underscoring the growing momentum behind the Global Fund’s mission. Anglo American committed US$4.5 million to strengthen diagnostics, surveillance and global health security. GSK and ViiV Healthcare pledged GBP 6 million to continue support for community-led efforts to improve women and girls’ access to quality health care.
Goodbye Malaria reaffirmed its leadership with a US$5.5 million contribution to sustain malaria elimination efforts in Eswatini, Mozambique and South Africa. The Johnson & Johnson Foundation and the Skoll Foundation pledged US$5 million and US$6 million respectively to continue their support to countries to professionalize community health workers across Africa. Takeda renewed its support with an additional JPY 350 million to scale the successful integrated care model developed over the past five years. Foundation S continued its support with US$5 million to advance the Global Fund’s efforts to address the health impacts of the changing climate in the most affected communities.
The Rockefeller Foundation renewed its support for a third time, pledging US$10 million to help vulnerable communities, save lives and accelerate the transition to more resilient health systems. The Global Fund also welcomed a new €5 million commitment to diagnostics and imaging systems strengthening from Siemens Healthineers, a longstanding partner.
Beyond financial pledges, private sector partners pledged non-financial or co-investment support. Roche committed US$1 million in technical assistance to strengthen the diagnostic ecosystem and improve health care waste management. HELP Logistics, part of the Kühne Foundation, pledged to support the optimization of national health supply chain systems. Co-investment partnerships also include innovation funder Grand Challenges Canada.
Continuing partnerships include Zenysis, who pledged US$5.8 million in co-investment to continue to support the Global Fund’s investments in AI and the digital transformation of health systems. Orange, SC Johnson, Project Last Mile and Johnson & Johnson also renewed their commitments to support countries strengthen best-in-class approaches to behavior change and prevention programs, as well as supply chain and logistics.
Together, these commitments represent a powerful demonstration of collective action – with businesses and philanthropies investing not only to save lives today, but to build stronger, more resilient health systems for the future. These commitments highlight the private sector’s pivotal role in driving innovation, access and sustainability, ensuring that transformative tools and solutions reach the people who need them most, as quickly as possible. The focus now turns to deepening partnerships and sustaining innovations at scale. Building on a proven model that delivers measurable impact, the Global Fund offers a powerful platform for business and philanthropies to shape the future of global health – from expanding equitable access to lifesaving tools to harnessing technologies like AI to reach millions more people.
At the Summit, leaders reaffirmed that this momentum cannot stop here. The partnership will continue its efforts to mobilize further contributions toward the ambitious goal to raise US$2 billion from the private sector.