About the Global Fund

Published: 10 September 2025

Our Mission

The Global Fund is a worldwide partnership to defeat AIDS, tuberculosis (TB) and malaria and ensure a healthier, safer and more equitable future for all. We raise and invest up to US$5 billion a year to fight deadly infectious diseases, challenge the injustice that fuels them, and strengthen health and community systems in more than 100 of the hardest hit countries.

We unite world leaders, communities, civil society, health workers and the private sector to find solutions that have the most impact, and we take them to scale worldwide. Since 2002, our partnership has saved 70 million lives.

We are the world’s largest multilateral funder of global health grants in low- and middle-income countries, disbursing over US$69 billion to countries since 2002. We know that with science, money, political will and leadership, we can fight and overcome the deadliest disease threats.

The Global Fund is proof that by working hand-in-hand with civil society, governments, private sector partners, philanthropists, technical partners and communities affected by the diseases, we can save lives and dramatically change the course of HIV, TB and malaria.

Our Model

With over 20 years’ experience fighting infectious diseases, our model is proven to be an effective investment driven by impact.

Our model is anchored by partnership, making us a global movement of civil society, governments, private sector partners, philanthropists, technical partners and communities affected by the diseases in more than 100 countries.

Countries take the lead in determining where and how to best fight AIDS, TB, and malaria, tailoring their own response and taking into consideration their political, cultural and epidemiological context.

Communities are at the heart of everything we do. To achieve the greatest impact against the three diseases, we challenge power dynamics to ensure affected communities have an equal voice in the fight and an equal chance at a healthy future. Communities affected by HIV, TB and malaria participate at all levels of the response, and by strengthening their leadership we ensure the response is better tailored to their needs.

We raise funds on a three-year cycle, bringing longer term predictability in the fight against the diseases and in reinforcing resilient and sustainable health and community systems.

Our Board sets the strategy, governs the institution and approves all funding decisions. It includes members from donor and implementer governments, non-governmental organizations, the private sector, private foundations and affected communities.

The power of our partnership allows us to lower prices of lifesaving medicines and health equipment and increase the quality of vital health tools. As one of the largest providers of health commodities, the Global Fund supports over 120 countries in deploying health innovations at scale and at affordable prices.

Our Next Generation Market Shaping framework aims to shape innovation and accelerate new product introductions at scale; promote capacity building for regional manufacturing; and drive environmentally sustainable procurement and supply chains.

Our Impact

Over the past two decades, the Global Fund partnership has helped save 70 million lives, reduce the combined death rate from AIDS, TB, and malaria by 63% and significantly increase life expectancy in low- and middle-income countries.

The Global Fund provides 26% of all international financing for HIV programs, 73% of all international financing for TB programs and 59% of all international financing for malaria programs. Our investments save lives today and help countries build the capacity to prevent, identify and respond to future health threats.

By investing in the treatment and prevention of HIV, TB and malaria, we also strengthen countries’ overall health systems. Our investments boost quality of care, data tracking, accountability and governance, and service delivery. And by reducing the burden of HIV, TB and malaria, we also free up the capacity of health systems for other important health priorities.

Looking Ahead

Born out of crisis and built for resilience, the Global Fund partnership has, over the last 23 years, unwaveringly pursued its mission to end AIDS, TB and malaria as public health threats, despite numerous challenges. In recent years, our progress against the three diseases has come under increasing strain from a convergence of global crises. Conflict and displacement, the erosion of human rights, economic instability, deepening inequalities and an increase in extreme weather events all fuel the spread of disease and disrupt response efforts. At the same time, AMR and emerging and resurgent diseases like mpox and Ebola expose the fragility of health systems worldwide and the growing risk of future pandemics.

This fraught context is now compounded by a challenging global health funding landscape. The potential human toll could be immense, and put progress in the fight against AIDS, TB and malaria in jeopardy.

But the Global Fund remains committed and determined. Time and again, crises have tested our resolve, and time and again, our partnership has responded with resilience and agility. In the last two decades, our partnership has adapted to save lives and serve the people most affected by infectious diseases in an increasingly complex global landscape.

Read the Latest Results Report

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