The United States is a leader in the global fight against HIV, tuberculosis (TB) and malaria, and has been the Global Fund's largest donor since the partnership was founded in 2002.
The United States has contributed US$27.61 billion to date to the Global Fund. The country announced a commitment of US$4.6 billion to the Global Fund for the Eighth Replenishment.
The Global Fund is the largest multilateral provider of grants to strengthen health security, and invests in community health workers, disease surveillance systems, diagnostic tools, laboratory networks, commodities, and supply chains.
By working with countries to help prevent, diagnose and treat HIV, TB and malaria, the Global Fund strengthens local health systems and health security. These efforts save lives in low- and middle-income countries and keep Americans safe.
U.S. support for the Global Fund is also a strategic investment in the United States by delivering efficient and effective outcomes and turning taxpayer dollars into life-saving interventions that strengthen U.S. national security and the U.S. economy.
Government donor ranking
As of: end 2024
1
Contributions
Data updated on: 12 December 2025
Cumulative
Total contributed
US$27.61 billion
Shared Priorities
Like the United States, the Global Fund is committed to helping governments increase domestic investments in fighting HIV, TB and malaria, and is working with countries to plan for a transition from international assistance.
The U.S. government served as the institutional lead for the Multilateral Organization Performance Assessment Network's latest assessment of the Global Fund. This respected independent watchdog's assessment commended the Global Fund for its clear strategic direction, risk management, transparency, accountability and low operational budget.
The Global Fund is laser-focused on results and transparency and holds itself accountable to donors like the United States. The Global Fund contracts Local Fund Agents to verify the distribution of funding and achievement of results in implementing countries. The Global Fund also has a strong, independent Inspector General that reports directly to the Global Fund Board.
Like the United States, the Global Fund values its collaboration with faith-based organizations (FBOs), which are key implementing partners in reaching the most vulnerable. The Global Fund has disbursed over $4 billion to FBOs to date to fund lifesaving programs. FBOs are also important members of the Global Fund’s Country Coordinating Mechanisms. Many church groups also galvanize support for the Global Fund.