Over the last 20 years, the private and philanthropic sectors have played an essential role in supporting the Global Fund to achieve remarkable results, providing funding, developing and deploying essential pharmaceuticals and commodities, innovating products and technology solutions, and funding catalytic investments.
For private sector donors, the Global Fund represents a unique opportunity to achieve impact at scale, by enabling the deployment of private sector resources in targeted ways to complement and catalyze much larger funding flows from public donors and domestic resources. The Global Fund’s catalytic investments provide private sector donors with the benefits of the Global Fund’s scale, efficiency and influence, while also allowing them to focus their contributions where they can add the most value.
Our private sector partners have been a central part of our model since our inception – relentless dynamos of innovation and bold allies in the fight against HIV, tuberculosis (TB) and malaria – having committed nearly US$5.3 billion over the last 20 years.
In addition to core funding, catalytic investment opportunities present the possibility to ensure fundamental, positive and sustainable shifts in progress for global health.
Private sector investments through the Global Fund support critical catalytic areas that take advantage of a greater risk appetite, focus on specific aligned priorities, leverage private sector capabilities and networks, and rapidly scale solutions through the Global Fund’s unparalleled set of development assets:
The Global Fund’s Eighth Replenishment is a moment for philanthropists, foundations and companies to make a transformative impact on the world’s deadliest infectious diseases. With the right resources, and by optimizing the deployment of tools to fight diseases, we can dramatically accelerate progress toward ending AIDS, TB and malaria as public health threats.
A total of US$2 billion of private sector funding would save 2.5 million lives and deliver a return on investment of 1:19, with every dollar invested in fighting HIV, TB and malaria resulting in US$19 in health gains and economic returns.
Private Sector Investment Opportunity
Saving more than 2 million lives together
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Early Detection for Rapid Response: Strengthening Disease Surveillance Across West Africa
Catalytic funds are designed to accelerate adoption of innovation at scale and increase progress on essential programming. They are aligned with country priorities and complementary to the core funding the Global Fund provides.
Our catalytic investment portfolio represents strategic areas where private sector expertise and resources can be uniquely powerful and leverage the Global Fund’s unparalleled ability to rapidly scale innovative solutions that deliver lasting impact.
Critical areas include accelerating access to the next generation of pharmaceutical and commodity solutions; deeper integration of program services driving women’s health and gender equality; human resources, including community health workers; climate and health; collaborative surveillance; and digital health, including the use of AI.
Innovations like revolutionary HIV drugs and mosquito nets have saved millions of lives. But COVID-19, Ebola, and other disease outbreaks reveal stark global inequities in access to lifesaving tools.
The Global Fund actively shapes markets to deliver cutting-edge health products quickly and fairly. We focus on improving system capacity to track, trace and optimize delivery. For malaria, we've scaled up dual active ingredient insecticide-treated mosquito nets, with 59% of current procurements offering better resistance against mosquitoes. For HIV, we’ve signed a landmark access agreement with Gilead Sciences to introduce lenacapavir in low- and middle-income countries alongside high-income markets. We are also working with partners to accelerate country readiness, ensure affordability and foster competition – positioning lenacapavir as a next-generation HIV prevention tool.
Innovation saves lives – and the Global Fund ensures it reaches those who need it most.
From mpox to the Marburg virus, the world is facing a surge in deadly outbreaks. The Global Fund is investing in resilient health and community systems — the frontline defense against today’s and tomorrow’s health threats.
We’re strengthening laboratories, disease surveillance and supply chains with powerful backing from private partners. With tools for early diagnosis and detection, as well as enabling the regional deployment of early warning platforms, such as Senegal’s proven 4s system, in collaboration with the Pasteur Institute, we’re detecting threats faster and saving lives sooner. Global health security starts here.
The Laboratory Systems Integration Fund (LSIF) — supported by The Rockefeller Foundation, the Abbott Fund, IQVIA through (RED) and matched by the Global Fund — is investing US$54 million to modernize laboratory systems in 49 countries.
Already, US$37 million has been deployed to improve diagnostics, integrate services and strengthen regional collaboration. These efforts enhance not only current responses to HIV, TB and malaria, but also pandemic preparedness.
With over US$720 million invested since 2014, together with the private sector, we’re making digital health work for the people who need it most.
Digital innovation is transforming global health — and the Global Fund is at the forefront. Since 2014, the
Global Fund has invested more than US$720 million, and currently invests more than US$150 million a year, to strengthen health information systems and improve data availability and quality for HIV, TB, malaria and other health programs in over 100 countries. From mobile X-rays for TB to connected diagnostics, our partnerships are helping frontline workers reach further, faster.
In 2024, the launch of the US$50 million Digital Health Impact Accelerator (DHIA) Catalytic Fund — backed by a coalition of private sector partners including Anglo American and the Patrick J McGovern Foundation — gave countries new tools to harness the power of digital health and AI.
From AI-powered TB screening in Gabon, Mongolia, Tanzania and Ukraine to the electrification and digital connection of hundreds of rural health facilities, DHIA is delivering results where they are needed most. These are not isolated pilots. They are investments in long-term infrastructure, governance and system readiness, helping countries embed digital solutions at scale.
Gender inequality fuels the spread of HIV, TB and malaria — especially among women and girls. Every week, 4,000 young women globally are infected with HIV. Malaria threatens 1 in 3 pregnancies in Africa. The Global Fund is tackling these inequities head-on.
We invest in integrated care for women’s health, empowered community health workers, support for women-led organizations and action against gender-based violence. Together, these efforts are transforming health systems and driving lasting change for women and girls worldwide. GSK and ViiV Healthcare partnered with us to support the launch of the Gender Equality Fund, an ambitious initiative aimed at empowering women, girls and gender-diverse communities to influence health-related policies and programs.
In most countries, community health workers, who are predominantly unpaid women, play an essential role in ensuring women, girls and marginalized populations can access basic primary health care services. Paying, training and integrating community health workers into formal health systems is key to improving health outcomes for everyone, but especially for women and girls.
In 2022, the Global Fund, the Johnson & Johnson Foundation, the Skoll Foundation and other partners launched the Africa Frontline First Initiative – a catalytic fund to mobilize US$100 million to ensure community health workers are trained, supervised and paid as professional health care workers across eight African countries.
Rising temperatures and extreme weather are fueling malaria spread and disrupting health services. Cyclones and floods destroy facilities and displace communities, worsening disease outbreaks and treatment gaps.
Between 2024 and 2026, 71% of our investments will target the 50 most climate-vulnerable countries. The Global Fund is committed to supporting these communities, tackling climate-driven health crises, and responding swiftly to urgent needs.
Launched in 2025 with Foundation S (Sanofi Collective) and the Gates Foundation , our new Climate and Health Catalytic Fund tackles the growing climate-health crisis head-on. With an initial US$50 million, we're scaling innovation, strengthening health systems, and reaching the most vulnerable communities. Now, we need bold investment to meet surging global demand.
The Global Fund is continuously looking for new partnerships and funding sources to accelerate the end of AIDS, tuberculosis and malaria as epidemics.
The broad range of private and nongovernment partners engaging with the Global Fund understand that investing in health equals investing in markets, people and the long-term profitability of their businesses. Partnering with the Global Fund also brings visibility, recognition and opportunities to further develop businesses.