Eighth Replenishment Stop At Nothing.

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Published: 04 November 2025

The Global Fund’s Eighth Replenishment Summit took place on Friday, 21 November 2025, in Johannesburg, South Africa. This Summit marks a pivotal moment to accelerate the fight to end AIDS, TB and malaria, strengthen resilient and sustainable health systems, and build a healthier, safer future for all.

As co-hosts, South Africa and the UK are championing solidarity, sustainability, innovation, equity and reform — principles at the heart of the Global Fund’s partnership model.

The event convened heads of state and government, civil society, communities, multilateral and bilateral partners, and the private sector to secure the investments needed to expand lifesaving health programs.

Together, we have the opportunity to save up to 23 million lives and move closer to a world free from the deadliest infectious diseases. We must stop at nothing to end AIDS, TB and malaria.

Global Fund Board Welcomes Final Eighth Replenishment Outcome of US$12.64 Billion, Backs Strategic Shifts to Advance Countries’ Path to Self-Reliance

Global Fund Partners Demonstrate Unity and Resolve to Sustain Progress and Strengthen Global Health Security

Global Fund Private Sector Partners to Drive Innovation, Equity, Access and Impact in Global Health

Pledges at Global Fund Eighth Replenishment

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Pledges at Global Fund Eighth Replenishment - Private Sector and Non-Government Donors

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Global Fund partners demonstrate unity and resolve to sustain the fight against AIDS, tuberculosis (TB) and malaria, save millions more lives, and strengthen systems for health at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, which was held on 21 November, 2025, on the margins of the G20 Leaders’ Summit. From left to right: Nuradeen Zakariyya, entrepreneur and advocate for universal health coverage; Ani Herna Sari, TB advocate and chair of the Rekat Peduli Indonesia Foundation; Global Fund Executive Director Peter Sands; South African President Cyril Ramaphosa; Global Fund Board Chair Lady Roslyn Morauta; Ivan Molina Aranibar, HIV advocate and Global Fund Youth Council member; and Sibulele Sibaca Nomnganga, global health advocate and social change engineer.

Scenes ahead of the Global Fund’s Eighth Replenishment Summit at Sandton Convention Centre in Johannesburg, South Africa, on 21 November 2025.

Scenes ahead of the Global Fund’s Eighth Replenishment Summit at Sandton Convention Centre in Johannesburg, South Africa, on 21 November 2025.

Preparations ahead of the Global Fund’s Eighth Replenishment Summit at Sandton Convention Centre in Johannesburg, South Africa, on 21 November 2025.

Front row from right to left: Lars Klingbeil, Vice Chancellor and Minister of Finance of Germany; Jonas Gahr Støre, Prime Minister of Norway; Peter Sands, Global Fund Executive Director; Cyril Ramaphosa, President of South Africa; Dr. Aaron Motsoaledi, Minister of Health of South Africa; Sir Keir Starmer MP, Prime Minister of the United Kingdom; Lady Roslyn Morauta, Global Fund Board Chair; and Micheál Martin, Taoiseach, Prime Minister of the government of Ireland.

Scenes at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Cecilia Lodonu-Senoo, speaking on behalf of the Communities, Developing Country NGOs and Developed Country NGOs Delegations to the Global Fund Board at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025. For Cecilia Lodonu-Senoo, the pledges made in Johannesburg carry deep meaning. “For people living with HIV, and for families affected by TB and malaria, these commitments mean access, dignity and hope,” she said. “Communities have always been at the center of this fight – and we will remain at the heart of what comes next.”

Co-moderator Azania Mosaka at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Global Fund Executive Director Peter Sands speaks at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025. “Our world has changed. Irreversibly. The old model is over. The new one is just emerging. Today we start shaping it. Rediscovering the shared spirit and determination that inspired the birth of this extraordinary partnership. Reinventing it to meet today’s realities.”

Global Fund Executive Director Peter Sands speaks at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025. “With shared purpose, renewed urgency and unshakable solidarity, we can beat the deadliest diseases, and build a healthier, fairer, more resilient world. When this partnership is united and determined, nothing can stop us. We cannot stop now. We will not stop now.”

Co-moderator Henry Bonsu at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Amina J. Mohammed, Deputy Secretary-General of the United Nations, delivers a video message to the audience at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Global Fund Board Chair Lady Roslyn Morauta speaks at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Cynthia Termorshuizen, Deputy Minister, G7 Summit and Personal Representative of the Prime Minister (Sherpa) for G7 and G20, Canada, speaks at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

From left to right: Luisa Engel, Chief Strategy and Impact Officer at (RED); Emily Gibbons, Senior Director, International Government Affairs & Policy, Gilead Sciences; and Dr. Jared Baeten, Senior Vice President, Clinical Development Virology Therapeutic Area Head, Gilead Sciences at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Shambhulingappa Hakki, Joint Secretary for Multilateral Economic Relations and G20 Divisions, and Sous Sherpa for the G20 and BRICS, India (left) at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Audiences watch as Bill Gates, Chair and Board Member, Gates Foundation, delivers a video message at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

South African spoken word poet, writer and performer Xabiso Vili (center) is joined by global health advocates in an inspiring on-stage performance at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025. The advocates’ stories are woven into the patterned fabrics they wear. Four fighters. Four journeys that speak to something far greater: our shared humanity and our vision of a better future. Each pattern tells a story of determination, purpose and the human spirit that rises again and again. From left to right on stage: Ani Herna Sari from Indonesia, Nuradeen Zakariyya from Nigeria, Xabiso Vili (center), Ivan Molina Aranibar from Bolivia and Sibulele Sibaca Nomnganga from South Africa.

At the Summit, President Cyril Ramaphosa of South Africa underlined Africa’s growing leadership in global health: “Hosting this Replenishment on African soil for the first time symbolizes how far we have come – and how far we can go,” he said. “Africa is not only leading in implementation; we are also driving innovation and taking greater responsibility for our own health systems. This partnership embodies solidarity, equity and transformation.”

Members of the audience at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Dr. Muhammad Ali Pate, Coordinating Minister of Health & Social Welfare, Nigeria, delivers a video message to the audience at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

At the Summit, Sir Keir Starmer, Prime Minister of the United Kingdom, stressed the value of investing in the Global Fund.  “In today’s volatile world, we must prioritise spending that makes a genuine difference and supports both growth at home and globally,” he said. “That is why we will continue to support the Global Fund, whose work is at the cutting edge of fighting the world’s deadliest diseases. It is an investment in economic growth and stability, and a prime example of our modern approach to development.”

A fan made from Indonesian TB advocate Ani Herna Sari’s fabric on display at the Global Fund’s Eighth Replenishment Summit in Johannesburg on 21 November 2025.

Sherwin Charles, CEO and Co-founder of Goodbye Malaria, and member of the Global Fund Board representing the private sector, speaks at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

A powerful performance by South Africa’s Ndlovu Youth Choir at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Norwegian Prime Minister Jonas Gahr Støre reaffirmed Norway’s commitment to the Global Fund  at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

Scenes from the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, on 21 November 2025.

South African spoken word poet, writer and performer Xabiso Vili (left) and global health advocate Sibulele Sibaca Nomnganga (right) cheer at the Global Fund’s Eighth Replenishment Summit in Johannesburg, South Africa, 21 November 2025.

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